The vehicles collided on Waterloo Road near Colony Road in Allamuchy Township, the local fire department said.
The victims were evaluated at the scene while emergency crews cleared a minor fluid spill.
The victims were identified as a 51-year-old Stanhope man and a 26-year-old Andover woman, WRNJ reports citing NJSP Trooper Brandi Slota.
State Police were investigating the cause of the crash.
Click here to follow Daily Voice Cresskill-Closter and receive free news updates.